2-Amino-6-chloro-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine

Names

[ Name ]:
2-Amino-6-chloro-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine

[Synonym ]:
2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyl tetrahydrofuran-3,4-diol
2-amino-6-chloro-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purine

Biological Activity

[Description]:

2-Amino -6-chloro-9-(2-β-C-methyl-β-D-ribofuranosyl)-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₄ClN₅O₄

[ Molecular Weight ]:
315.71

[ Exact Mass ]:
315.07300

[ PSA ]:
139.54000