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Allomatrine

Names

[ CAS No. ]:
641-39-4

[ Name ]:
Allomatrine

[Synonym ]:
13S-HYDROXY-6Z,9Z,11E-OCTADECATRIENOIC ACID
4-(2-Biphenylyl)-1-(hydroxymethyl)-10-oxa-4-azatricyclo[5.2.1.0]dec-8-ene-3,5-dione
13-hydroxy-(6Z,9Z,11E,13S)-6,9,11-octadecatrienoic acid
13(S)-HYDROXY-9(Z),11(E),15(Z)-OCTADECATRIENOIC ACID
(13S,6Z,9Z,11E)-hydroxyoctadeca-6,9,11-trienoic acid
Allomatrine
13-hydroxy-6,9,11-octadecatrienoic acid
4,7-Epoxy-1H-isoindole-1,3(2H)-dione, 2-[1,1'-biphenyl]-2-yl-3a,4,7,7a-tetrahydro-4-(hydroxymethyl)-
(+)-Allomatrin
13(S)-HOT
13(S)-HYDROXYOCTADECA-6Z,9Z,11E-TRIENOIC ACID
13(S)-HOTE
(6Z,9Z,11E)-13(S)-hydroxyoctadeca-6,9,11-trienoic acid

Biological Activity

[Description]:

Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Long Pan, et al. Chemical Constituents of Alkaloids From the Bark of Sophora Japonica. Zhong Yao Cai. 2016 Sep;39(9):2027-9.

[2]. Seiichi Kobashi , et al. Antinociceptive Effects of 1-acyl-4-dialkylaminopiperidine and 1-alkyl-4-dialkylaminopiperidine in Mice: Structure-Activity Relation Study of Matrine-Type Alkaloids. Biol Pharm Bull. 2002 Aug;25(8):1030-4.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
638.7±55.0 °C at 760 mmHg

[ Melting Point ]:
106-107 ℃

[ Molecular Formula ]:
C15H24N2O

[ Molecular Weight ]:
347.364

[ Flash Point ]:
340.1±31.5 °C

[ Exact Mass ]:
347.115753

[ PSA ]:
66.84000

[ LogP ]:
2.09

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.666

[ Storage condition ]:
2-8C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds