dodecanoic-2,2-d2 acid

Names

[ Name ]:
dodecanoic-2,2-d2 acid

[Synonym ]:
Lauric-2,2-d2 acid
2,2-di-2H-lauric acid
Dodecanoic acid-2,2-d2
2,2-Dideuteriododanoic acid
2,2-dideuterio-dodecanoic acid
2,2-Dideuterio-dodecansaeure
MFCD00053326

Biological Activity

[Description]:

Lauric acid-d2 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Nakatsuji T, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009 Oct;129(10):2480-8.

Chemical & Physical Properties

[ Boiling Point ]:
225ºC100 mm Hg(lit.)

[ Melting Point ]:
44-46ºC(lit.)

[ Molecular Formula ]:
C₁₂H₂₂D₂O₂

[ Molecular Weight ]:
202.33

[ Flash Point ]:
113ºC

[ Exact Mass ]:
202.19000

[ PSA ]:
37.30000

[ LogP ]:
3.99190

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-28

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

dodecanoic-2,2-d2 acid

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds