2′-Deoxy-2′-fluoroadenosine

Names

[ Name ]:
2′-Deoxy-2′-fluoroadenosine

[Synonym ]:
2'F-dA
2'-Deoxy-2'-fluoroadenosine
2'-fluoro-2'-deoxy-adenosine
Adenosine, 2'-deoxy-2'-fluoro-
Adenosine,2'-deoxy-2'-fluoro

Biological Activity

[Description]:

2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
628.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂FN₅O₃

[ Molecular Weight ]:
269.232

[ Flash Point ]:
334.0±34.3 °C

[ Exact Mass ]:
269.092407

[ PSA ]:
119.31000

[ LogP ]:
-0.32

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.834

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%