BRD 6989

Names

[ CAS No. ]:
642008-81-9

[ Name ]:
BRD 6989

[Synonym ]:
3-Quinolinecarbonitrile, 2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-
2-Amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydro-3-quinolinecarbonitrile
MFCD04013193

Biological Activity

[Description]:

A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM); inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM.

[References]

References 1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108. View Related Products by Target Cyclin-dependent Kinase (CDK)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
496.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₆N₄

[ Molecular Weight ]:
264.325

[ Flash Point ]:
254.2±28.7 °C

[ Exact Mass ]:
264.137512

[ LogP ]:
3.69

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.640

BRD 6989

Names

Biological Activity

Chemical & Physical Properties

Related Compounds