Boc-N-Amido-PEG3-azide

Names

[ CAS No. ]:
642091-68-7

[ Name ]:
Boc-N-Amido-PEG3-azide

[Synonym ]:
5,8,11-Trioxa-2-azatridecanoic acid,13-azido-,1,1-dimethylethyl ester
t-Boc-N-Amido-PEG3-Azide
1-Boc-amine-11-azido-3,6,9-trioxaundecane

Biological Activity

[Description]:

Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₂₆N₄O₅

[ Molecular Weight ]:
318.36900

[ Exact Mass ]:
318.19000

[ PSA ]:
119.26000

[ LogP ]:
1.52836

Boc-N-Amido-PEG3-azide

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Related Compounds