Guanethidine sulfate

Names

[ CAS No. ]:
645-43-2

[ Name ]:
Guanethidine sulfate

[Synonym ]:
1-[2-(Azocan-1-yl)ethyl]guanidine sulfate (1:1)
EINECS 211-442-0
Iporal
Guanethidine bisulfate
1-[2-(1-Azocanyl)ethyl]guanidine sulfate
Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (1:1)
2-[2-(azocan-1-yl)ethyl]guanidine,sulfuric acid
Sanotensin
MFCD00035403
1-[2-(1-Azocanyl)ethyl]guanidine sulfate (1:1)
1-[2-(Azocan-1-yl)ethyl]guanidine sulfate
Guanethidine Sulfate
Ismelin sulfate
UNII-5UBY8Y002G
Guanetidin sulfate
Guanethidine monosulfate
1-[2-(Azocan-1-yl)ethyl]guanidinsulfat
N-(2-Guanidino ethyl)heptamethylenimine sulfate
1-(2-azocan-1-ylethyl)guanidine sulfate
Ismelin
guanethidine sulphate

Biological Activity

[Description]:

Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Fabiani ME, et al. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res. 1996 Mar;33(3):171-80.

[2]. Joyce PI, et al. The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
345.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₂₄N₄O₄S

[ Molecular Weight ]:
296.387

[ Flash Point ]:
162.8ºC

[ Exact Mass ]:
296.151825

[ PSA ]:
148.12000

[ LogP ]:
2.29240

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF3150000

CAS REGISTRY NUMBER :: 645-43-2

LAST UPDATED :: 198809

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H22-N4.H2-O4-S

MOLECULAR WEIGHT :: 296.44

WISWESSER LINE NOTATION :: T8NTJ A2MYZUM &S-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,592,1967 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 321,57,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S25-S36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
MF3150000

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%