<Suppliers Price>

AL-3138

Names

[ CAS No. ]:
64603-03-8

[ Name ]:
AL-3138

Biological Activity

[Description]:

AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandin F2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[In Vitro]

AL-3138 对 A7r5 细胞和 3T3 细胞的作用EC50 值分别为 72.2 nM 和 20.5 nM。此外，AL-3138 在 A7r5 细胞中对氟苯尼考的作用被确定为 Ki = 296 nM 和 Kb = 182 nM[1]。

[References]

[1]. Sharif NA, et al. AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation: comparison with some purported FP antagonists. J Pharm Pharmacol. 2000 Dec;52(12):1529-39.   

Chemical & Physical Properties

[ Molecular Formula ]:
C20H33FO4

[ Molecular Weight ]:
356.47

Related Compounds