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L-Leucyl-L-Leucine methyl ester hydrochloride

Names

[ CAS No. ]:
6491-83-4

[ Name ]:
L-Leucyl-L-Leucine methyl ester hydrochloride

[Synonym ]:
leucylleucinemethylesterhydrochloride
HCl*H-L-Leu2-OMe
L-Leucine, L-leucyl-, methyl ester, hydrochloride (1:1)
(-) H-Leu-Leu-OMe*HCl
L-Leucyl-L-Leucine methyl ester (hydrochloride)
leucylleucine methyl ester hydrochloride
(Leu)2-OMe hydrochloride
Methyl L-leucyl-L-leucinate hydrochloride (1:1)
L-leucinyl-leucine methyl ester hydrochloride

Biological Activity

[Description]:

L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress[1][2][3].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

L-Leucyl-L-Leucine methyl ester (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells[3]. L-Leucyl-L-Leucine methyl ester (10-250 μM; 15 min) is converted to a CCI3COOH-insoluble product by CD4- lymphocytes[2].

[References]

[1]. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48.

[2]. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7.

[3]. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423.

Chemical & Physical Properties

[ Melting Point ]:
171-181 °C

[ Molecular Formula ]:
C13H27ClN2O3

[ Molecular Weight ]:
294.818

[ Exact Mass ]:
294.171021

[ PSA ]:
81.42000

[ LogP ]:
2.95690

Related Compounds