Ethyl 2-oxo-4-phenylbutanoate

Names

[ Name ]:
Ethyl 2-oxo-4-phenylbutanoate

[Synonym ]:
Ethyl 2-oxo-4-phenylbutanoate
2-oxo-4-phenyl-butyric acid ethyl ester
BENZYLPYRUVIC ACID ETHYL ESTER
EINECS 265-276-9
2-oxo-4-phenylhexanoate
MFCD00037533
Ethy 2-oxo-4-phenylbutyrate
Ethyl-2-oxo-4-phenylbutanoat
ethyl 2-keto-4-phenylbutyrate
4-phenyl-2-oxobutyric acid ethyl ester
Benzenebutanoic acid, α-oxo-, ethyl ester
Ethyl 4-phenyl-2-oxobutanoate
ethyl 2-oxo-4-phenyl-butyrate
KETO ESTER
ETHYL-2 OXO-4 PHENYL BUTANOATE
ETHYL BENZYLPYRUVATE
ETHYL-2-OXO-4-PHENYLBUTRATE
2-oxo-4-phenylbutanoic acid ethyl ester

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
309.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₄O₃

[ Molecular Weight ]:
206.238

[ Flash Point ]:
140.0±19.2 °C

[ Exact Mass ]:
206.094299

[ PSA ]:
43.37000

[ LogP ]:
2.24

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.506

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Efficient synthesis of a chiral precursor for angiotensin-converting enzyme (ACE) inhibitors in high space-time yield by a new reductase without external cofactors.

Org. Lett. 14(8) , 1982-5, (2012)

A new reductase, CgKR2, with the ability to reduce ethyl 2-oxo-4-phenylbutyrate (OPBE) to ethyl (R)-2-hydroxy-4-phenylbutyrate ((R)-HPBE), an important chiral precursor for angiotensin-converting enzy...

Scalable biocatalytic synthesis of optically pure ethyl (R)-2-hydroxy-4-phenylbutyrate using a recombinant E. coli with high catalyst yield.

J. Biotechnol. 168(4) , 493-8, (2013)

Ethyl (R)-2-hydroxy-4-phenylbutanoate [(R)-HPBE] is a versatile and important chiral intermediate for the synthesis of angiotensin-converting enzyme (ACE) inhibitors. Recombinant E. coli strain coexpr...

Effect of ionic liquid [BMIM][PF6] on asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate by Saccharomyces cerevisiae.

J. Ind. Microbiol. Biotechnol. 35(11) , 1419-24, (2008)

The effect of ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]) on the asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate (EOPB) to synthesize optical active ethyl 2-hydroxy...