<Suppliers Price>

Pyrimidinone 8

Names

[ CAS No. ]:
65004-42-4

[ Name ]:
Pyrimidinone 8

[Synonym ]:
4(1H)-Pyrimidinone, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-
4(3H)-pyrimidinone, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-
MFCD01416214
2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-methyl-4(1H)-pyrimidinone
MFCD00097142
2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol

Biological Activity

[Description]:

Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM; does not affect hDMT1 cell surface expression and shows no dependence on extracellular pH.

[References]

References 1. Montalbetti N, et al. Biochem Pharmacol. 2015 Aug 1;96(3):216-24. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
410.4±48.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H12N4O

[ Molecular Weight ]:
204.229

[ Flash Point ]:
202.0±29.6 °C

[ Exact Mass ]:
204.101105

[ LogP ]:
1.28

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.650

Related Compounds