m-PEG8-thiol

Names

[ CAS No. ]:
651042-83-0

[ Name ]:
m-PEG8-thiol

[Synonym ]:
2,5,8,11,14,17,20,23-octaoxapentacosane-25-thiol

Biological Activity

[Description]:

m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.07

[ Molecular Formula ]:
C₁₇H₃₆O₈S

[ Molecular Weight ]:
400.52800

[ Exact Mass ]:
400.21300

[ PSA ]:
112.64000

[ LogP ]:
0.67880

[ Storage condition ]:
2-8°C

m-PEG8-thiol

Names

Biological Activity

Chemical & Physical Properties

Related Compounds