1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Names

[ Name ]:
1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE

[Synonym ]:
AGEPC
Blood platelet activating factor-acether
1-O-Alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine
Antihypertensive polar renomedullary lipid
Platelet activating factor phosphatidate

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₅₄NO₇P

[ Molecular Weight ]:
523.68300

[ Exact Mass ]:
523.36400

[ PSA ]:
103.93000

[ LogP ]:
6.69400

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EC6060000

CHEMICAL NAME :: Blood platelet-activating factor

CAS REGISTRY NUMBER :: 65154-06-5

LAST UPDATED :: 199609

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14800 ng/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 40,227P,1986

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-38-40-48/20/22

[ Safety Phrases ]:
36/37-24/25-22

[ RIDADR ]:
UN 1888 6.1/PG 3

[ RTECS ]:
EC6060000

Articles

Platelet-activating factor phosphatidate, but not platelet-activating factor, is a powerful calcium ionophore in the human red cell.

Cell Calcium 5(5) , 463-73, (1984)

Platelet-activating factor (1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, PAF) is a potent inducer of shape-change, aggregation and secretion in platelets. PAF causes a rapid increase in intrace...