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(D-Ala2)-Leu-Enkephalin amide

Names

[ CAS No. ]:
65189-64-2

[ Name ]:
(D-Ala2)-Leu-Enkephalin amide

[Synonym ]:
Leu-enkephalinamide,ala(2)
enkephalinamide-Leu,Ala(2)
2-Ala-leu-enkephalinamide
Enkephalinamide-leu,alanine(2)
DALEA
Leucine-enkephalinamide,ala(2)
DALE
(D-Ala2)-Leu-Enkephalin amide
Ala(2)-Enkephalinamide-Leu

Biological Activity

[Description]:

[D-Ala2] Leu-Enkephalinamide is an enkephalin analog. [D-Ala2] Leu-Enkephalinamide has great corneal permeability and analgesic effect. [D-Ala2] Leu-Enkephalinamide can be used for the research of ocular diseases[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

[D-Ala2] Leu-Enkephalinamide (MEA) (1.0 mM; 10-240 min) has great corneal permeability in vitro[1].

[In Vivo]

D-Ala2-Leu-enkephalinamide (s.c.) is also enhanced in morphine-dependent animals[2].

Chemical & Physical Properties

[ Molecular Formula ]:
C29H40N6O6

[ Molecular Weight ]:
568.66400

[ Exact Mass ]:
568.30100

[ PSA ]:
220.69000

[ LogP ]:
4.83780

Related Compounds