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Bedaquiline (Mixture of DiastereoMers)

Names

[ CAS No. ]:
654655-80-8

[ Name ]:
Bedaquiline (Mixture of DiastereoMers)

[Synonym ]:
N-desmethyl bedaquiline
6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol
1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol

Biological Activity

[Description]:

(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[References]

[1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Jun;55(6):483-487.  

[2]. Sarathy JP, et al. TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01540-19.  

Chemical & Physical Properties

[ Molecular Formula ]:
C32H31BrN2O2

[ Molecular Weight ]:
555.50

[ Exact Mass ]:
554.15700

[ PSA ]:
45.59000

[ LogP ]:
7.13050

Related Compounds