Thozalinone

Names

[ CAS No. ]:
655-05-0

[ Name ]:
Thozalinone

[Synonym ]:
2-Dimethylamino-5-phenyl-4-oxazolinon-(4)
Tozalinona [INN-Spanish]
2-Oxazolin-4-one,2-(dimethylamino)-5-phenyl
5-Phenyl-2-dimethylamino-2-oxazolin-4-on
2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one
2-Dimethylamino-5-phenyl-4-oxo-2-oxazolin
2-Dimethylamino-4-oxo-5-phenyl-oxazolin
Tozalinonum [INN-Latin]
Stimsen
2-dimethylamino-5-phenyl-oxazol-4-one
Tozalinone
THOZALINONE

Biological Activity

[Description]:

Thozalinone also known as 5phenyl-2-dimethylamino-2-oxazolin-4-one, is an excitant with activity against Tetrabenazine depression. Thozalinone has unique properties distinguishing them from the sympathomimetic amines[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Greenblatt EN, et al. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965 Jul;7(4):566-78.

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
294.8ºC at 760 mmHg

[ Melting Point ]:
134.5ºC

[ Molecular Formula ]:
C₁₁H₁₂N₂O₂

[ Molecular Weight ]:
204.23

[ Flash Point ]:
132.1ºC

[ Exact Mass ]:
204.09000

[ PSA ]:
41.90000

[ LogP ]:
0.63770

[ Index of Refraction ]:
1.584

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ5775000

CHEMICAL NAME :: 2-Oxazolin-4-one, 2-(dimethylamino)-5-phenyl-

CAS REGISTRY NUMBER :: 655-05-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H12-N2-O2

MOLECULAR WEIGHT :: 204.25

WISWESSER LINE NOTATION :: T5NV DO CHJ CR& EN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3000 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - somnolence (general depressed activity)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1240 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%