iKIX1

Names

[ Name ]:
iKIX1

[Synonym ]:
2-(Cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazinecarbothioamide
3-[(2-Cyanoacetyl)amino]-1-(3,4-dichlorophenyl)thiourea
MFCD00119122
iKIX1
2-(2-cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazine-1-carbothioamide
Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide

Biological Activity

[Description]:

A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM; blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection; a novel therapeutic strategy in fungal infectious disease.

[References]

References 1. Nishikawa JL, et al. Nature. 2016 Feb 25;530(7591):485-9. View Related Products by Target Fungal

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₀H₈Cl₂N₄OS

[ Molecular Weight ]:
303.168

[ Exact Mass ]:
301.979584

[ LogP ]:
2.26

[ Index of Refraction ]:
1.681