(E/Z)-Polydatin

Names

[ Name ]:
(E/Z)-Polydatin

[Synonym ]:
3,4,5-Tsg
trans-polydatin
MFCD00210592
(E)-Polydatin
Trans-Piceid
Giant knotweed Extract
Piceid
Reservatrol-3-β-mono-D-glucoside
Polydatin

Biological Activity

[Description]:

(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Du QH, et al. Polydatin: a review of pharmacology and pharmacokinetics. Pharm Biol. 2013 Nov;51(11):1347-54.

Chemical & Physical Properties

[ Density]:
1.521 g/cm3

[ Boiling Point ]:
707.7ºC at 760 mmHg

[ Melting Point ]:
223-226 °C(lit.)

[ Molecular Formula ]:
C₂₀H₂₂O₈

[ Molecular Weight ]:
407.39100

[ Flash Point ]:
381.8ºC

[ Exact Mass ]:
407.13400

[ PSA ]:
160.07000

[ LogP ]:
0.49640

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Protective effect of polydatin against burn-induced lung injury in rats.

Respir. Care 59(9) , 1412-21, (2014)

Polydatin (PD) has anti-inflammatory and anti-apoptotic effects in ischemic-reperfusion injury. Moreover, inflammatory responses and apoptosis play a role in the development of burn-induced lung injur...

Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway.

Oxid. Med. Cell. Longev. 2015 , 362158, (2015)

Oxidative stress and inflammation are involved in the pathogenesis in renal ischemia/reperfusion (I/R) injury. It has been demonstrated that polydatin processed the antioxidative, anti-inflammatory, a...

Pre-column incubation followed by fast liquid chromatography analysis for rapid screening of natural methylglyoxal scavengers directly from herbal medicines: case study of Polygonum cuspidatum.

J. Chromatogr. A. 1286 , 102-10, (2013)

Methylglyoxal (MGO), a very reactive metabolite of glucose, plays a pivotal role in the pathogenesis of several chronic diseases associated with diabetes, and it has been validated as an attractive ta...