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Ac-Arg-Gly-Lys(Ac)-MCA

Names

[ CAS No. ]:
660846-97-9

[ Name ]:
Ac-Arg-Gly-Lys(Ac)-MCA

[Synonym ]:
MFCD08458544
N2-Acetyl-L-arginylglycyl-N6-acetyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide
L-Lysinamide, N2-acetyl-L-arginylglycyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Biological Activity

[Description]:

Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[In Vitro]

Following initial inhibition of HDACs, the peptide substrate Ac-Arg-Gly-Lys-AMC is added to the reaction tubes for next 30 min and finally the stop solution stopped the reaction mediated by HDAC enzymes[1].

[References]

[1]. Meike Kespohl, et al. The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4 + T Cells Front Immunol. 2017 Aug 28;8:1036.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C28H40N8O7

[ Molecular Weight ]:
600.667

[ Exact Mass ]:
600.302002

[ LogP ]:
-1.46

[ Index of Refraction ]:
1.630

[ Storage condition ]:
-20°C

Related Compounds