3-Hydroxyterphenyllin

Names

[ Name ]:
3-Hydroxyterphenyllin

[Synonym ]:
3',6'-Dimethoxy-(1,1':4',1''-terphenyl)-2',3,4,4''-tetrol
TERPHENYLLIN,HYDROXY
3-Hydroxyterphenyllin
Hydroxyterphenyllin
4-[2-hydroxy-4-(4-hydroxyphenyl)-3,6-dimethoxyphenyl]benzene-1,2-diol
AmbotzLS-1090

Biological Activity

[Description]:

3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Kurobane I, et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by H and C nuclear magnetic resonance spectroscopy. J Antibiot (Tokyo). 1979;32(6):559-564.

[2]. Wang Y, et al. 3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells. Int J Oncol. 2017;50(4):1392-1402.

Chemical & Physical Properties

[ Density]:
1.353g/cm3

[ Boiling Point ]:
542.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₈O₆

[ Molecular Weight ]:
354.35300

[ Flash Point ]:
282.1ºC

[ Exact Mass ]:
354.11000

[ PSA ]:
99.38000

[ LogP ]:
3.86020

[ Index of Refraction ]:
1.657

Safety Information

[ HS Code ]:
2909499000

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%