Gly MCA

Names

[ Name ]:
Gly MCA

[Synonym ]:
Gly-β-MCA

Biological Activity

[Description]:

Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR

Research Areas >> Metabolic Disease

[Target]

FXR[1].

[In Vitro]

Gly-β-MCA, a bile acid, is a potent, sable and intestine-selective and farnesoid X receptor (FXR) inhibitor[1]. Gly-β-MCA (Gly-MCA, ) is resistant to hydrolysis by BSH[1].

[In Vivo]

Gly-β-MCA (Gly-MCA, p.o. 10 and 50 mg/kg) prevents and treats diet-induced and genetic obesity, along with insulin resistance and hepatic steatosis without systemic, hepatic or intestinal toxicities in mice[1]. Gly-MCA does not increase faecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation[1].

[References]

[1]. Jiang C, et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun. 2015 Dec 15;6:10166.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₄₃NO₆

[ Molecular Weight ]:
465.62

Gly MCA

Names

Biological Activity

Chemical & Physical Properties

Related Compounds