TRPM4-IN-2

Names

[ Name ]:
TRPM4-IN-2

Biological Activity

[Description]:

TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

[Target]

TRPM4:0.16 μM (IC50)

[In Vitro]

TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145[1]. Cell Proliferation Assay[1] Cell Line: DU145 Concentration: 50 μM Incubation Time: 0-500 s Result: Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.

[References]

[1]. Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665.

[2]. Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₄ClNO₄

[ Molecular Weight ]:
355.77

TRPM4-IN-2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds