Dehydronifedipine

Names

[ Name ]:
Dehydronifedipine

[Synonym ]:
dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate
Dehydronifedipine
B 4759
Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
Nifedipine Impurity 1

Chemical & Physical Properties

[ Density]:
1.284g/cm3

[ Boiling Point ]:
443.7ºC at 760 mmHg

[ Melting Point ]:
100-105ºC

[ Molecular Formula ]:
C₁₇H₁₆N₂O₆

[ Molecular Weight ]:
344.31900

[ Flash Point ]:
222.1ºC

[ Exact Mass ]:
344.10100

[ PSA ]:
111.31000

[ LogP ]:
3.37000

[ Appearance of Characters ]:
powder | yellow

[ Index of Refraction ]:
1.575

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Nuclear translocation of nuclear transcription factor-kappa B by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons.

Mol. Pharmacol. 63(4) , 784-90, (2003)

We describe a new molecular mechanism of cell death by excitotoxicity mediated through nuclear transcription factor kappa B (NF kappa B) in rat embryonic cultures of dopaminergic neurons. Treatment of...

Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha.

PLoS ONE 9(4) , e94885, (2014)

Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell...

Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.

Drug Metab. Dispos. 42(8) , 1235-40, (2014)

Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk...