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For-Met-Leu-Phe-Lys-OH

Names

[ CAS No. ]:
67247-11-4

[ Name ]:
For-Met-Leu-Phe-Lys-OH

[Synonym ]:
L-Lysine,N-formyl-L-methionyl-L-leucyl-L-phenylalanyl
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]hexanoic acid
FOR-MET-LEU-PHE-LYS-OH
FOR-MET-LEU-PHE-LYS
N-Formyl-Met-Leu-Phe-Lys

Biological Activity

[Description]:

N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D2817.32G, respectively[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

EC50: 3.5 nM (FPR1), 6.7 μM (FPR2), 0.88 μM (FPR2-D2817.32G)[1]


[References]

[1]. He HQ, et al. Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands. J Biol Chem. 2014 Jan 24;289(4):2295-306.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H43N5O6S

[ Molecular Weight ]:
565.73

[ Exact Mass ]:
565.29300

[ PSA ]:
205.02000

[ LogP ]:
3.71070

Related Compounds