Kaurenoic acid

Names

[ Name ]:
Kaurenoic acid

[Synonym ]:
Kaurenoic acid
Cunabic acid
(5β,8α,9β,10α,13α)-Kaur-16-en-18-oic acid
(5β,8α,9β,10α)-Kaur-16-en-18-oic acid
KAUREN-19-OIC ACID
Kaurane-16-ene-18-oic acid
ent-kaur-16-en-19-oic acid

Biological Activity

[Description]:

Kaurenoic acid is a diterpene from Sphagneticola trilobata, inhibits Inflammatory Pain by the inhibition of cytokine production and activation of the NO–cyclic GMP–PKG–ATP-sensitive potassium channel signaling pathway[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. Mizokami SS, et al. Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. J Nat Prod. 2012 May 25;75(5):896-904.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
426.6±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₀O₂

[ Molecular Weight ]:
302.451

[ Flash Point ]:
202.8±20.3 °C

[ Exact Mass ]:
302.224579

[ PSA ]:
37.30000

[ LogP ]:
6.37

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.550

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Development and validation of two methods based on high-performance liquid chromatography-tandem mass spectrometry for determining 1,2-benzopyrone, dihydrocoumarin, o-coumaric acid, syringaldehyde and kaurenoic acid in guaco extracts and pharmaceutical preparations.

J. Sep. Sci. 34(7) , 740-8, (2011)

In this study, two HPLC-ESI-MS/MS methods were developed and validated for the determination of 1,2-benzopyrone (COU), o-coumaric acid (OCA), kaurenoic acid (KAU), syringaldehyde (SYR), and dihydrocou...

Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis.

Pharmacol. Biochem. Behav. 109 , 38-43, (2013)

The herbal preparations of Annona senegalensis Pers. (Annonaceae) root bark are used in Nigerian ethnomedicine for the treatment of epilepsy and febrile seizures. The scientific evidence for this effe...

Biosynthesis of uterotonic diterpenes from Montanoa tomentosa (zoapatle).

J. Plant Physiol. 166(18) , 1961-7, (2009)

Montanoa tomentosa (zoapatle) is a Central American plant used in Mexico in traditional herbal medicine to ease childbirth labor and to cure certain female disorders. Recently, crude extracts of M. to...