CID3528206

Names

[ Name ]:
CID3528206

[Synonym ]:
N4-(3-Fluorophenyl)-N2-methyl-5-nitro-2,4,6-pyrimidinetriamine
N4-(3-fluorophenyl)-N2-methyl-5-nitropyrimidine-2,4,6-triamine
2,4,6-Pyrimidinetriamine, N4-(3-fluorophenyl)-N2-methyl-5-nitro-

Biological Activity

[Description]:

CID3528206 is a potent, small molecule yeast TORC1 inhibitor that inhibits TORC1 activity both in vitro and in vivo with IC50 of 150 nM and 3.9 uM, respectively; alters GFP expression in all five GFP clones in a manner analogous to that of rapamycin, inhibits yeast cell growth.

[References]

References 1. Chen J, et al. ACS Chem Biol. 2012 Apr 20;7(4):715-22. View Related Products by Target mTOR

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
493.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₁FN₆O₂

[ Molecular Weight ]:
278.242

[ Flash Point ]:
252.5±31.5 °C

[ Exact Mass ]:
278.092743

[ LogP ]:
1.91

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.736