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CXCR4 antagonist 1

Names

[ CAS No. ]:
675135-69-0

[ Name ]:
CXCR4 antagonist 1

Biological Activity

[Description]:

CXCR4 antagonist 1 is a potent CXCR4 antagonist. CXCR4 antagonist 1 has anti-HIV activity[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> GPCR/G Protein >> CXCR

Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4

HIV

[In Vitro]

HIV-1 entry is triggered by interaction of gp120 with CD4 and chemokine receptors (CKRs), such as CCR5 and CXCR4[1].

[References]

[1]. Yuta Hikichi, et al. Increased HIV-1 Sensitivity to Neutralizing Antibodies by Mutations in the Env V3-coding Region for Resistance to CXCR4 Antagonists. J Gen Virol. 2016 Sep;97(9):2427-2440.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₄₃N₇

[ Molecular Weight ]:
465.68

Related Compounds