NSD3-IN-2

Names

[ CAS No. ]:
675190-57-5

[ Name ]:
NSD3-IN-2

Biological Activity

[Description]:

NSD3-IN-2 is a potent NSD3 inhibitor with an IC50 value of 17.97 μM. NSD3-IN-2 inhibits the growth and proliferation of non-small cell lung cancer cell lines H460, H1299 and H1650 with anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[In Vitro]

NSD3-IN-2 (化合物 C6) (30 μM; 48 h) 抑制 H460、H1299、H1560 细胞中 H3K36me3 的表达[1]。 NSD3-IN-2 (50 μM; 7-16 d) 抑制 H460、H1299、H1560 细胞增殖，但对 A549 细胞无抑制作用[1]。

[References]

[1]. Piao Lianhua, et al. Application of compound C6 as histone methyltransferase NSD3 inhibitor: China, CN109223794[P].2019-01-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H15N5OS

[ Molecular Weight ]:
337.40

Related Compounds