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MRK 560

Names

[ CAS No. ]:
677772-84-8

[ Name ]:
MRK 560

Biological Activity

[Description]:

MRK-560 is a potent, orally bioavailable and brain-penetrant γ-secretase inhibitor[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

γ-secretase[1]


[References]

[1]. Best JD, et al. The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H17ClF5NO4S2

[ Molecular Weight ]:
517.92

[ Exact Mass ]:
517.02100

[ PSA ]:
97.07000

[ LogP ]:
7.22170

Related Compounds