Etamicastat hydrochloride
Names
[ CAS No. ]:
677773-32-9
[ Name ]:
Etamicastat hydrochloride
[Synonym ]:
(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride
(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione hydrochloride
Biological Activity
[Description]:
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2].
[Related Catalog]:
[Target]
IC50: 107 nM (DBH)[1]
[In Vitro]
Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL (141 μM)[2].
[In Vivo]
Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels[1]. Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats[1]. Animal Model: NMRi mice[1] Dosage: 100 mg/kg Administration: Administered intraperitoneally Result: Led to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control). Animal Model: Male Wistar rats[1] Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: Orally administered with at a dose volume of 10 mL/kg Result: Oral bioavailability (64%), Cmax (4.9 nM), and (T1/2=3.7 h).
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C14H16ClF2N3OS
[ Molecular Weight ]:
347.81100
[ Exact Mass ]:
347.06700
[ PSA ]:
88.06000
[ LogP ]:
4.00360