Mcl-1-Puma inhibitor 8

Names

[ Name ]:
Mcl-1-Puma inhibitor 8

Biological Activity

[Description]:

Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Mcl-1:0.3 μM (Ki)

[References]

[1]. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₃N₃O₂S

[ Molecular Weight ]:
393.50

Mcl-1-Puma inhibitor 8

Names

Biological Activity

Chemical & Physical Properties

Related Compounds