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12-Hydroxyabieta-8,12-diene-11,14-dione

Names

[ CAS No. ]:
6812-87-9

[ Name ]:
12-Hydroxyabieta-8,12-diene-11,14-dione

[Synonym ]:
1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-
12-Hydroxyabieta-8,12-diene-11,14-dione
1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione
12-Hydroxy-13-isopropylpodocarpa-8,12-diene-11,14-dione
7α-12-Hydroxy-8,12-abietadiene-11,14-dione

Biological Activity

[Description]:

Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

mTOR/PI3/AKT[1]


[In Vitro]

Royleanone (0-200 μM; 48 h) 以剂量依赖性方式抑制 LNCaP 癌细胞的活力，IC50 为 12.5 μM[1]。

[References]

[1]. Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
426.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H28O3

[ Molecular Weight ]:
316.43

[ Flash Point ]:
225.8±25.2 °C

[ Exact Mass ]:
316.203857

[ PSA ]:
54.37000

[ LogP ]:
6.18

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.548

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds