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Chonglou Saponin VII

Names

[ CAS No. ]:
68124-04-9

[ Name ]:
Chonglou Saponin VII

[Synonym ]:
(3β,25R)-17-Hydroxyspirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1-&gt;4)-6-deoxy-α-L-mannopyranosyl-(1-&gt;4)]-
Paris saponin VII

Biological Activity

[Description]:

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> PARP
Signaling Pathways >> Apoptosis >> Caspase
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

Akt

p38

Bcl-2

Caspase-9

Caspase-3

PARP-1


[In Vitro]

Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase[1].

[In Vivo]

Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice[2].

[References]

[1]. Yan T, et al. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907.

[2]. Li Y, et al. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C51H82O21

[ Molecular Weight ]:
1031.184

[ Exact Mass ]:
1030.534912

[ PSA ]:
314.83000

[ LogP ]:
4.91

[ Index of Refraction ]:
1.629

[ Storage condition ]:
-20℃

Related Compounds