Piperazine-1,4-bis(2-hydroxypropanesulfonic acid) dihydrate

Names

[ Name ]:
Piperazine-1,4-bis(2-hydroxypropanesulfonic acid) dihydrate

[Synonym ]:
3,3'-Piperazine-1,4-diylbis(2-hydroxypropane-1-sulfonic acid)
MFCD00038350
3,3'-(1,4-Piperazinediyl)bis(2-hydroxy-1-propanesulfonic acid)
EINECS 269-199-1
2-hydroxy-3-[4-(2-hydroxy-3-sulfopropyl)piperazin-1-yl]propane-1-sulfonic acid
1,4-Piperazinedipropanesulfonic acid, β,β'-dihydroxy-

Biological Activity

[Description]:

POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Ng LT, et al. Effect of buffers and osmolality on anion uniport across the mitochondrial inner membrane. Biochim Biophys Acta. 1993 Jun 10;1143(1):29-37.

[2]. Vasconcelos, et al. Influence of zwitterionic pH buffers on the bioavailability and toxicity of copper to the alga Amphidinium carterae. 2009 Nov;19(10):2542-2550.

[3]. Kebede N, et al. Electrogenerated chemiluminescence of tris(2,2' bipyridine)ruthenium(II) using common biological buffers as co-reactant, pH buffer and supporting electrolyte. Analyst. 2015 Nov 7;140(21):7142-5.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Melting Point ]:
320°C

[ Molecular Formula ]:
C₁₀H₂₂N₂O₈S₂

[ Molecular Weight ]:
362.420

[ Exact Mass ]:
362.081757

[ PSA ]:
172.44000

[ LogP ]:
-4.05

[ Index of Refraction ]:
1.593

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
1 M NaOH: 0.1 M, clear, colorless

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
21-23/24/25-25-36/37/38

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%