3-nitro-2-pyridinesulfenyl chloride

Names

[ Name ]:
3-nitro-2-pyridinesulfenyl chloride

[Synonym ]:
3-Nitro-2-pyridinesulfenyl chloride
3-nitropyridine-2-sulfenyl chloride
3-nitro-2-pyridinylsulfenyl chloride
Pyridine,2-chlorothio-3-nitro
2-Pyridinesulfenyl chloride,3-nitro
3-nitropyridinesulfenyl chloride
3-nitro-pyridin-2-ylsulfenyl chloride
Npys-Cl
Npys
MFCD00274609
3-Nitro-2-pyridinesulfenyl

Chemical & Physical Properties

[ Density]:
1.58g/cm3

[ Boiling Point ]:
376.8ºC at 760mmHg

[ Melting Point ]:
205ºC (dec.)(lit.)

[ Molecular Formula ]:
C₅H₃ClN₂O₂S

[ Molecular Weight ]:
190.60800

[ Flash Point ]:
181.7ºC

[ Exact Mass ]:
189.96000

[ PSA ]:
84.01000

[ LogP ]:
2.75890

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
dichloromethane: soluble(lit.)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
26-27-36/37/39-45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Articles

Synthesis of disulfide-bridged fragments of omega-conotoxins GVIA and MVIIA. Use of Npys as a protecting/activating group for cysteine in Fmoc syntheses.

Int. J. Pept. Protein Res. 43(4) , 363-6, (1994)

The 3-nitro-2-pyridinesulphenyl (Npys) moiety is finding increasing utility as a protecting-activating group for cysteine, particularly in the synthesis of cyclic and unsymmetrical disulfides using th...

Synthesis and stability of 3-nitro-2-pyridinesulfenyl chloride (NpysCl).

Int. J. Pept. Protein Res. 42(2) , 159-64, (1993)

3-Nitro-2-pyridinesulfenyl chloride (NpysCl) is the starting material for the synthesis of N-, O- and S-Npys-protected amino acids. Two efficient, novel synthetic routes to NpysCl are described. The s...

Discriminative affinity labelling of opioid receptors by enkephalin and morphiceptin analogues containing 3-nitro-2-pyridinesulphenyl-activated thiol residues.

J. Chromatogr. A. 597(1-2) , 425-8, (1992)

The thiol groups of leucinthiol, cysteamine and cysteine incorporated into opioid peptides enkephalin and morphiceptin were activated by the 3-nitro-2-pyridinesulphenyl (Npys) group to form mixed disu...