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Cytostatin

Names

[ CAS No. ]:
682329-63-1

[ Name ]:
Cytostatin

[Synonym ]:
(2S,5S,6S,7S,8Z,10Z,12E)-7-Hydroxy-6-methyl-2-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8,10,12-tetradecatrien-5-yl dihydrogen phosphate
2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-, (5S,6S)-

Biological Activity

[Description]:

Cytostatin is a potent and selective inhibitor of PP2A with promising antitumor activity. Cytostatin belongs to the fostriecin family of natural products[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

PP2A[1]


[References]

[1]. Lawhorn BG, et al. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. J Am Chem Soc. 2006;128(51):16720-16732.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
645.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H33O7P

[ Molecular Weight ]:
428.456

[ Flash Point ]:
344.0±34.3 °C

[ Exact Mass ]:
428.196381

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±4.4 mmHg at 25°C

[ Index of Refraction ]:
1.529

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds