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2-Hydroxy-3-(hydroxymethyl)anthraquinone

Names

[ CAS No. ]:
68243-30-1

[ Name ]:
2-Hydroxy-3-(hydroxymethyl)anthraquinone

[Synonym ]:
3-hydroxy-2-hydroxymethylanthraquinone
2-hydroxy-3-hydroxymethylanthraquinone
2-Hydroxy-3-hydroxymethyl-anthraquinone
3-hydroxy-2-hydroxymethyl anthraquinone
2-hydroxymethyl-3-hydroxyanthraquinone
3-hydroxy-2-(hydroxymethyl)anthraquinone

Biological Activity

[Description]:

2-Hydroxymethyl-3-hydroxyanthraquinone is an antiosteoporotic compound that inhibits osteoclastic tartrate-resistant acid phosphatase (TRAP) activity[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Others

[Target]

TRAP[1]


[In Vitro]

2-Hydroxymethyl-3-hydroxyanthraquinone (0.1-10 μM; 48 h) 剂量依赖性抑制破骨细胞TRAP 活性，降低骨片上破骨细胞骨吸收坑面积[1]。

[References]

[1]. Wu YB, et al. Antiosteoporotic activity of anthraquinones from Morinda officinalis on osteoblasts and osteoclasts. Molecules. 2009 Jan 23;14(1):573-83.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H10O4

[ Molecular Weight ]:
254.23700

[ Exact Mass ]:
254.05800

[ PSA ]:
74.60000

[ LogP ]:
1.65990

Related Compounds