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1-Methyl-2-nonylquinolin-4(1H)-one

Names

[ CAS No. ]:
68353-24-2

[ Name ]:
1-Methyl-2-nonylquinolin-4(1H)-one

[Synonym ]:
1-Methyl-2-nonyl-4(1H)-quinolinone
4(1H)-Quinolinone, 1-methyl-2-nonyl-
N-methyl-2-nonyl-4-quinolone
1-Methyl-2-nonyl-4(1H)-quinolone
1-Methyl-2-n-nonyl-4-chinolon
1-methyl-2-nonyl-1H-quinolin-4-one

Biological Activity

[Description]:

1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC50 of 12.1 μM[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[Target]

MAO-B

MAO-A


[In Vitro]

1-Methyl-2-nonyl-4(1H)-quinolone shows more potent inhibitory effects against MAO-B compared to MAO-A[1].

[References]

[1]. Han XH, et al. Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. Arch Pharm Res. 2007 Apr;30(4):397-401.

[2]. Adams M, et al. Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med. 2004 Oct;70(10):904-8.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
391.9±42.0 °C at 760 mmHg

[ Melting Point ]:
73-75℃

[ Molecular Formula ]:
C19H27NO

[ Molecular Weight ]:
285.424

[ Flash Point ]:
132.6±17.3 °C

[ Exact Mass ]:
285.209259

[ PSA ]:
22.00000

[ LogP ]:
6.09

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.524

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds