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(+/-)-Pinocembrin

Names

[ CAS No. ]:
68745-38-0

[ Name ]:
(+/-)-Pinocembrin

[Synonym ]:
(2S)-5,7-dihydroxyflavanone
(2S)-2,3-dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one
(2S)-pinocembrin
dihydrochrysin
pinocembrin
5,7-Dihydroxyflavanone
Galangin flavanone

Biological Activity

[Description]:

(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> GPCR/G Protein >> GPR120

[In Vitro]

(±)-Pinocembrin shows wound-healing effect (EC50=0.07 µM), probably involves other mechanisms besides GPR120 activation[1].

[References]

[1]. Mazzotta S, et al. Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway. Bioorg Chem. 2021;108:104657.

Chemical & Physical Properties

[ Density]:
1.386g/cm3

[ Boiling Point ]:
520.6ºC at 760 mmHg

[ Melting Point ]:
202-203ºC

[ Molecular Formula ]:
C15H12O4

[ Molecular Weight ]:
256.25300

[ Flash Point ]:
203.3ºC

[ Exact Mass ]:
256.07400

[ PSA ]:
66.76000

[ LogP ]:
2.80430

[ Vapour Pressure ]:
1.85E-11mmHg at 25°C

[ Index of Refraction ]:
1.661

[ Storage condition ]:
2-8°C

Related Compounds