BCR-ABL-IN-7

Names

[ Name ]:
BCR-ABL-IN-7

[Synonym ]:
3-Isoxazolecarboxamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-(4-fluorophenyl)-

Biological Activity

[Description]:

BCR-ABL-IN-7 (compound 4) is a WT and T315I mutant ABL kinases inhibitor. BCR-ABL-IN-7 effectively inhibits activities of WT and T315I mutant ABL kinases. BCR-ABL-IN-7 can be used for the research of chronic myeloid leukemia (CML) research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

[References]

[1]. Cao R, et al. Discovery of 2-Acylaminothiophene-3-Carboxamides as Multitarget Inhibitors for BCR-ABL Kinase and Microtubules. J Chem Inf Model. 2015 Nov 23;55(11):2435-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆FN₃O₃S

[ Molecular Weight ]:
385.41

BCR-ABL-IN-7

Names

Biological Activity

Chemical & Physical Properties

Related Compounds