Oxantel (pamoate)

Names

[ Name ]:
Oxantel (pamoate)

[Synonym ]:
Telopar (TN)
EINECS 272-332-6
UNII-UPY1D732T0
Telopar
HMS2093L04
Oxantel embonate
Oxantel pamoate (USAN)
OXANTEL PAMOATE
Oxantel (pamoate)

Biological Activity

[Description]:

Oxantel pamoate is a widely available dewormer, potently against Trichuris muris and Hookworms.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[Target]

Antiparasitic[1]

[In Vivo]

The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus[1].

[References]

[1]. Keiser J, et al. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug. PLoS Negl Trop Dis. 2013;7(3):e2119.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.09 g/cm3

[ Boiling Point ]:
383.1ºC at 760 mmHg

[ Molecular Formula ]:
C₃₆H₃₂N₂O₇

[ Molecular Weight ]:
604.65

[ Flash Point ]:
185.5ºC

[ PSA ]:
186.72000

[ LogP ]:
7.41720

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Oxantel pamoate-albendazole for Trichuris trichiura infection.

N. Engl. J. Med. 370(7) , 610-20, (2014)

Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and often occur concomitantly. These parasitic-worm infections are typically treated...

Preventive anthelmintic chemotherapy--expanding the armamentarium.

N. Engl. J. Med. 370(7) , 665-6, (2014)

Mechanisms underlying gut dysfunction in a murine model of chronic parasitic infection.

Am. J. Physiol. Gastrointest. Liver Physiol. 299 , G1354-G1360, (2010)

Irritable bowel syndrome (IBS) is common in countries where chronic parasitic infestations are endemic. However, the relationship between parasitic infection and IBS is not clear. The aim of this stud...