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SPL 334

Names

[ CAS No. ]:
688347-51-5

[ Name ]:
SPL 334

[Synonym ]:
4-{[2-[(2-cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid
Benzoic acid, 4-[[2-[[(2-cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]-
4-({2-[(2-Cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl}methyl)benzoic acid
SPL-334
MFCD05032783

Biological Activity

[Description]:

SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> GSNOR
Research Areas >> Inflammation/Immunology

[In Vivo]

SPL-334 (0.1-1 mg/kg; 鼻内给药; 每日一次, 持续 7 天; 带有 DO11.10 CD4+ Th2 异种移植物的 BALB/c 受体小鼠) 导致过敏性气道炎症减少[1] . Animal Model: BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft[1] Dosage: 0.1 or 1 mg/kg Administration: Intranasal administration; daily, for 7 days Result: Caused a significant reduction in the influx of lymphocytes and eosinophils into the airways and the level of EPO in the BALF. Reduced the number of OVA-specific T cells and eosinophils during allergic airway inflammation. Reduced in peribronchial inflammation and mucus secretion during airway inflammation.

[References]

[1]. Ferrini ME, et, al. S-nitrosoglutathione reductase inhibition regulates allergen-induced lung inflammation and airway hyperreactivity. PLoS One. 2013 Jul 25;8(7):e70351.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
694.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H15N3O3S2

[ Molecular Weight ]:
433.503

[ Flash Point ]:
373.5±34.3 °C

[ Exact Mass ]:
433.055481

[ LogP ]:
3.85

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.721

Related Compounds