toltrazuril

Names

[ Name ]:
toltrazuril

[Synonym ]:
1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfanyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
1-Methyl-3-(3-methyl-4-{4-[(trifluoromethyl)sulfanyl]phenoxy}phenyl)-1,3,5-triazinane-2,4,6-trione
Bay Vi 9142
MFCD00867201
1-Methyl-3-[4-[p-[(trifluoromethyl)thio]phenoxy]-m-tolyl]-s-triazine-2,4,6(1H,3H,5H)-trione
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1-methyl-3-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl]-
Toltrazuril
EINECS 231-710-0
1-Methyl-3-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Biological Activity

[Description]:

Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.Target: AntiparasiticToltrazuril is an antiprotozoal agent that acts upon Coccidia parasites. Toltrazuril induces changes in the fine structure of coccidian development stages that are mainly due to a swelling of the endoplasmatic reticulum and of the Golgi apparatus and to abnormalities in the peri-nuclear space, disturbance in nuclear division. Treated with toltrazuril showed a considerably lower mean opg to that of group C (5.78 opg versus 144.62 opg) (p < 0.05) and a FOCR of 97.7 %. The higher efficacy (99.23 %) was observed at 15 days post treatment; however, the average efficacy of the drug remained extremely high (> 90 %) for all the study.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

Natural Products >> Others

[References]

[1]. Mehlhorn H, et al. Toltrazuril effective against a broad spectrum of protozoan parasites. Parasitol Res. 1988;75(1):64-6.

[2]. Diaferia M, et al. Efficacy of toltrazuril 5 % suspension (Baycox?, Bayer) and diclazuril (Vecoxan, Janssen-Cilag) in the control of Eimeria spp. in lambs. Parasitol Res. 2013 Aug;112 Suppl 1:163-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
194-196°C

[ Molecular Formula ]:
C₁₈H₁₄F₃N₃O₄S

[ Molecular Weight ]:
425.382

[ Exact Mass ]:
425.065704

[ PSA ]:
111.39000

[ LogP ]:
2.90

[ Index of Refraction ]:
1.640

[ Storage condition ]:
0-6°C

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R50/53

[ Safety Phrases ]:
S60-S61

[ RIDADR ]:
UN 3077

[ HS Code ]:
2933699090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933699090

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

Articles

Pharmacokinetics and improved bioavailability of toltrazuril after oral administration to rabbits.

J. Vet. Pharmacol. Ther. 33(5) , 503-6, (2010)

Necrotic enteritis due to simultaneous infection with Isospora suis and clostridia in newborn piglets and its prevention by early treatment with toltrazuril.

Parasitol. Res. 110(4) , 1347-55, (2012)

In this study, 51 piglets originating from five different sows were included in the investigations. The animal source of all sows had a history of Clostridium perfringens type A (β2) infection. The pi...

Determination of diclazuril, toltrazuril and its two metabolites in poultry tissues and eggs by gel permeation chromatography-liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(20) , 1757-63, (2011)

A new procedure has been described for the extraction of diclazuril (DIZ), toltrazuril (TOZ) and its two main metabolites toltrazuril sulphoxide (TZSO) and toltrazuril sulphone (TZS) from poultry tiss...