1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione

Names

[ Name ]:
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione

[Synonym ]:
2,4,5-Trihydroxypyrimidine
5-Hydroxyuracil
5-Hydroxy-1H-pyrimidin-2,4-dion
5-hydroxy-uridine
Pyrimidine-2,4,5-triol

Biological Activity

[Description]:

5-Hydroxy-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.848g/cm3

[ Molecular Formula ]:
C₉H₁₂N₂O₇

[ Molecular Weight ]:
260.20

[ Exact Mass ]:
260.06400

[ PSA ]:
145.01000

[ Index of Refraction ]:
1.698