Endosidin 9
Names
[ CAS No. ]:
693806-53-0
[ Name ]:
Endosidin 9
Biological Activity
[Description]:
Endosidin 9 (ES9) is a novel mitochondrial uncoupler, and a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems, strongly reduces FM4-64 uptake in Arabidopsis root cells with IC50 of 5 uM.Endosidin 9 (ES9) inhibits CME dynamics and organelle movement in the cytoplasm.Endosidin9 (ES9) inhibits clathrin-mediated endocytosis largely through cytoplasmic acidification.
[References]
1. Dejonghe W, et al. Nat Chem Biol. 2019 Jun;15(6):641-649. 2. Dejonghe W, et al. Nat Commun. 2016 Jun 8;7:11710.
Chemical & Physical Properties
[ Molecular Formula ]:
C10H7BrN2O4S2
[ Molecular Weight ]:
363.2