Rachelmycin
Names
[ CAS No. ]:
69866-21-3
[ Name ]:
Rachelmycin
[Synonym ]:
(+)-(3bR,4aS)-CC-1065
(+)-CC-1065
Rachelmycin
Biological Activity
[Description]:
Rachelmycin (CC-1065; NSC 298223) is a potent naturally antibiotic isolated from Streptomyces zelensis. Rachelmycin binds non-covalently and covalently (N-3 adenine adduct) in the minor groove of B-form DNA. Rachelmycin has exceptionally potent antitumor activity[1].
[Related Catalog]:
[In Vivo]
The smallest dose at which delayed death occurs is less for Rachelmycin (CC-1065; NSC 298223; 12.5 mg/kg) in experiments with non-tumored BDF1 mice[1].
[References]
Chemical & Physical Properties
[ Density]:
1.75g/cm3
[ Molecular Formula ]:
C37H33N7O8
[ Molecular Weight ]:
703.70000
[ Exact Mass ]:
703.23900
[ PSA ]:
210.31000
[ LogP ]:
4.62030
[ Index of Refraction ]:
1.878
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DF4936700
- CAS REGISTRY NUMBER :
- 69866-21-3
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C37-H33-N7-O8
- MOLECULAR WEIGHT :
- 703.77
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >8800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6900 ng/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 ug/kg
- TOXIC EFFECTS :
- Liver - fatty liver degeneration
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 7400 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,999,1982 *** REVIEWS *** TOXICOLOGY REVIEW JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 39,319,1986