Triphosphopyridine nucleotide sodium salt hydrate

Names

[ Name ]:
Triphosphopyridine nucleotide sodium salt hydrate

[Synonym ]:
|A-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate
Triphosphopyridine nucleotide sodium salt hydrate

Biological Activity

[Description]:

NADP sodium hydrate, a β-Nicotinamide adenine dinucleotide phosphate sodium salt, is a redox cofactor. NADP sodium hydrate is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH)[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Carugo O, et al. NADP-dependent enzymes. I: Conserved stereochemistry of cofactor binding. Proteins. 1997;28(1):10-28.

[2]. Zhao FL, et al. A genetically encoded biosensor for in vitro and in vivo detection of NADP(.). Biosens Bioelectron. 2016;77:901-906.

Chemical & Physical Properties

[ Melting Point ]:
175-178ºC (dec.)(lit.)

[ Molecular Formula ]:
C₂₁H₂₇N₇NaO₁₇P₃

[ Molecular Weight ]:
765.38700

[ Exact Mass ]:
765.05700

[ PSA ]:
400.87000

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P337 + P313

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Articles

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

PLoS ONE 10(1) , e0117842, (2015)

Mouse cytochrome P450 (CYP) 2A5 is induced by inflammatory conditions and infectious diseases that down-regulate the expression and activity of most other CYP isoforms. Enhanced oxidative stress and n...

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.

Nat. Rev. Drug Discov. 10 , 453-471, (2011)

NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery wall in conditions such as h...

The role of free radical generation in increasing cerebrovascular permeability.

Free Radic. Biol. Med. 51 , 967-977, (2011)

The brain endothelium constitutes a barrier to the passive movement of substances from the blood into the cerebral microenvironment, and disruption of this barrier after a stroke or trauma has potenti...