Ticlatone

Names

[ CAS No. ]:
70-10-0

[ Name ]:
Ticlatone

[Synonym ]:
6-chlorobenzisothiazolinone
6-CHLORO-1,2-BENZISOTHIAZOL-3(2H)-ONE
Ticlatonum [INN-Latin]
6-Chlor-3-oxo-2,3-dihydro-benzisothiazol
TICLATONE
6-chloro-1,2-benzisothiazol-3-one
6-chlorobenzo[d]isothiazol-3-one
Ticlatone [USAN:INN]
Landromil
Ticlatona [INN-Spanish]
6-chloro-1,2-benzisothiazolin-3-one
Fer 1443
6-Chloro-1,2-benzisothiazolone

Biological Activity

[Description]:

Ticlatone is an antifungal that can be used for the research of mycoses[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Lundell E, et, al. [Clinical studies on landromil (tiklaton) in treatment of mycoses]. Mykosen. 1971 Nov 1;14(11):531-3.

Chemical & Physical Properties

[ Density]:
1.515 g/cm3

[ Melting Point ]:
270-272ºC

[ Molecular Formula ]:
C₇H₄ClNOS

[ Molecular Weight ]:
185.63100

[ Exact Mass ]:
184.97000

[ PSA ]:
61.10000

[ LogP ]:
2.24300

[ Index of Refraction ]:
1.669

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4170000

CHEMICAL NAME :: 1,2-Benzisothiazolin-3-one, 6-chloro-

CAS REGISTRY NUMBER :: 70-10-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H4-Cl-N-O-S

MOLECULAR WEIGHT :: 185.63

WISWESSER LINE NOTATION :: T56 BSMVJ FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,1306,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,1306,1964

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%