2,4-dichloro-1-(4-chlorophenyl)benzene
Names
[ CAS No. ]:
7012-37-5
[ Name ]:
2,4-dichloro-1-(4-chlorophenyl)benzene
[Synonym ]:
2,4-dichloro-1-(4-chlorophenyl)benzene
Chemical & Physical Properties
[ Density]:
1.351g/cm3
[ Boiling Point ]:
330.3ºC at 760 mmHg
[ Melting Point ]:
206-207℃
[ Molecular Formula ]:
C12H7Cl3
[ Molecular Weight ]:
257.54300
[ Flash Point ]:
100ºC
[ Exact Mass ]:
255.96100
[ LogP ]:
5.31380
[ Index of Refraction ]:
1.603
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DV8840000
- CHEMICAL NAME :
- 1,1'-Biphenyl, 2,4,4'-trichloro-
- CAS REGISTRY NUMBER :
- 7012-37-5
- BEILSTEIN REFERENCE NO. :
- 1956846
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C12-H7-Cl3
- MOLECULAR WEIGHT :
- 257.54
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 273 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- REFERENCE :
- JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 49,301,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg/3D-I
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,94,1975 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 224 mg/kg
- SEX/DURATION :
- female 10-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 68,311,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 224 mg/kg
- SEX/DURATION :
- female 10-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 26,117,1995
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H304-H315-H336-H373-H410
[ Precautionary Statements ]:
P210-P260-P301 + P310-P331-P370 + P378-P403 + P235
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
N,Xn,F
[ Risk Phrases ]:
33-50/53-11
[ Safety Phrases ]:
35-60-61-62-33-29-16
[ RIDADR ]:
UN 2315
[ RTECS ]:
DV8840000
[ Packaging Group ]:
II
[ Hazard Class ]:
9
Synthetic Route
Articles
Environ. Int. 51 , 88-96, (2013)
Persistent organic pollutants (POPs) exert harmful effects on cognitive, endocrine and immune functions and bioaccumulate in the environment and human tissues. The aim of this study was to investigate...
Vertical distributions of organochlorine pesticides and polychlorinated biphenyls in an agricultural soil core from the Guanzhong Basin, China.Environ. Monit. Assess. 187(1) , 4159, (2015)
The concentrations and distributions of hexachlorocyclohexanes (HCHs), dichlorodiphenyltrichloroethanes (DDTs), and polychlorinated biphenyls (PCBs) in an agricultural soil core in the Guanzhong Basin...
Suppression of aromatase activity in vitro by PCBs 28 and 105 and Aroclor 1221.Toxicol. Lett. 152(1) , 91-100, (2004)
The effects of polychlorinated biphenyls (PCBs) on human cytochrome P450 aromatase activity in vitro were investigated using a commercially available microsomal fraction obtained from baculovirus infe...