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Nampt activator-1

Names

[ CAS No. ]:
701929-65-9

[ Name ]:
Nampt activator-1

Biological Activity

[Description]:

Nampt activator-1 (compound 1) is a potent Nicotinamide phosphoribosyltransferase (NAMPT) activator, with EC50 of 3.3-3.7 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

[References]

[1]. Akiu M, et al. Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.[J]. Bioorganic & medicinal chemistry letters, 2021, 43:128048.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₇N₃O₃

[ Molecular Weight ]:
299.32

Related Compounds